Estradiol-ERβ2 signaling axis confers growth and migration of CRPC cells through TMPRSS2-ETV5 gene fusion.

Estradiol-ERβ2 signaling axis confers growth and migration of CRPC cells through TMPRSS2-ETV5 gene fusion.

Oncotarget (2016-08-17)

Hogyoung Kim, Amrita Datta, Sudha Talwar, Sarmad N Saleem, Debasis Mondal, Asim B Abdel-Mageed

RESUMEN

Estrogen receptor beta (ERβ) splice variants are implicated in prostate cancer (PC) progression; however their underlying mechanisms remain elusive. We report that non-canonical activation of estradiol (E

MATERIALES

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R2625

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Ácido retinoico, ≥98% (HPLC), powder

GR11

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Anti-IGF-IR (Ab-1) Mouse mAb (αIR3), liquid, clone αIR3, Calbiochem^®

EHU036231

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MISSION^® esiRNA, targeting human TMPRSS2