Menin and PRMT5 suppress GLP1 receptor transcript and PKA-mediated phosphorylation of FOXO1 and CREB.

Menin and PRMT5 suppress GLP1 receptor transcript and PKA-mediated phosphorylation of FOXO1 and CREB.

American journal of physiology. Endocrinology and metabolism (2017-03-09)

Abdul Bari Muhammad, Bowen Xing, Chengyang Liu, Ali Naji, Xiaosong Ma, Rebecca A Simmons, Xianxin Hua

RESUMEN

Menin is a scaffold protein that interacts with several epigenetic mediators to regulate gene transcription, and suppresses pancreatic β-cell proliferation. Tamoxifen-inducible deletion of multiple endocrine neoplasia type 1 (

MATERIALES

Referencia del producto

Marca

Descripción del producto

E7144

Sigma-Aldrich

Exendin-4, ≥97%

05-1075

Sigma-Aldrich

Anticuerpo anti-FOXO1, clon 2H8.2, clone 2H8.2, from mouse