Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.

Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.

Organic letters (2005-05-07)

Benedek Vakulya, Szilárd Varga, Antal Csámpai, Tibor Soós

RESUMEN

Cinchona alkaloid-derived chiral bifunctional thiourea organocatalysts were synthesized and applied in the Michael addition between nitromethane and chalcones with high ee and chemical yields.

MATERIALES

Referencia del producto

Marca

Descripción del producto

360554

Sigma-Aldrich

Nitromethane, ACS reagent, ≥95%

230731

Sigma-Aldrich

Nitromethane, ReagentPlus^®, ≥99.0%

270423

Sigma-Aldrich

Nitromethane, suitable for HPLC, ≥96%

690481

Sigma-Aldrich

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8a,9S)-6′-methoxy-9-cinchonanyl]thiourea, 90%

690384

Sigma-Aldrich

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8a,9S)-10,11-dihydro-6′-methoxy-9-cinchonanyl]thiourea, 90%