- Synthesis and antimicrobial activity of new adamantane derivatives III.
Synthesis and antimicrobial activity of new adamantane derivatives III.
Farmaco (Societa chimica italiana : 1989) (2002-10-04)
Andrzej Orzeszko, Beata Kamińska, Bohdan J Starościak
PMID12361228
RESUMEN
Some novel ester imides synthesised from trimellitic acid anhydride and 1-adamantanol or 2-adamantanol, were tested as antimicrobial compounds. Unfortunately, these agents showed a modest antibacterial activity (MIC > 6 microg/ml). However, a comparison of these N-substituted adamantylester imides with the series published previously, indicated that the incorporation of L-alanine and L-phenylalanine into the phthalimide moiety was the best choice regardless of the series and leads to antimicrobial activity against Staphylococcus aureus strains.
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