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Merck

Histone methylation in transcriptional control.

Current opinion in genetics & development (2002-03-15)
Tony Kouzarides
RESUMEN

Over the past year or so, methylation of histones has come to be recognised as a major player in the regulation of gene activity. This notion follows the discovery of lysine and arginine methyltransferases and proteins that recognise the methyl-lysine 'mark' on histones. Methylated histones have been implicated in heterochromatic repression, promoter regulation and the propagation of a repressed state via DNA methylation.