- Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists.
Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists.
Bioorganic & medicinal chemistry letters (2004-12-18)
Gregory H Merriman, Liang Ma, Patrick Shum, Daniel McGarry, Frank Volz, Jeffrey S Sabol, Alexandre Gross, Zhicheng Zhao, David Rampe, Lin Wang, Friederike Wirtz-Brugger, Bruce A Harris, Douglas Macdonald
PMID15603968
RESUMEN
A series of 4,5-diarylimidazoline libraries were prepared using high-throughput solid-phase and microwave techniques. The compounds were evaluated as P2X(7) antagonists and their SAR is described.
MATERIALES
Referencia del producto
Marca
Descripción del producto
Número de referencia del producto (SKU)
Tamaño de envase
Disponibilidad
Precio
Cantidad