- Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells.
Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells.
Nature (1988-12-15)
J F Moreau, D D Donaldson, F Bennett, J Witek-Giannotti, S C Clark, G G Wong
PMID3143918
RESUMEN
Leukaemia inhibitory factor (LIF) is a cytokine that induces macrophage differentiation of the murine M1 myeloid leukaemia cell line. We have isolated a cDNA clone encoding a novel human haemopoietic growth factor, human interleukin for DA cells (HILDA) that supports the proliferation of the murine interleukin-3-dependent leukaemic cell line, DA-la (refs 3-5). HILDA proved to be identical to LIF. The demonstration that the differentiation factor LIF will also serve as a growth factor for at least one myeloid leukaemic cell line provides further evidence that the distinction between growth-promoting and differentiation-inducing activities are largely determined by the target cell type.