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1123000

USP

Chlorpheniramine maleate

Name: Chlorpheniramine maleate
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

(±)-Chlorpheniramine maleate salt

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About This Item

Fórmula empírica (notación de Hill):

C₁₆H₁₉ClN₂ · C₄H₄O₄

Número de CAS:

113-92-8

Peso molecular:

390.86

MDL number:

MFCD00069225

UNSPSC Code:

41116107

PubChem Substance ID:

329749337

NACRES:

NA.24

grade

pharmaceutical primary standard

API family

chlorpheniramine

manufacturer/tradename

USP

mp

130-135 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O

InChI

1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

DBAKFASWICGISY-BTJKTKAUSA-N

Gene Information

human ... HRH1(3269)

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Categorías relacionadas

Materiales de referencia analítica para la industria farmacéutica

Patrones de las farmacopeas y de los institutos metrológicos

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Chlorpheniramine maleate USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

Chlorpheniramine Maleate Tablets
Chlorpheniramine Maleate Oral Solution
Chlorpheniramine Maleate Extended-Release Capsules
Chlorpheniramine Maleate and Pseudoephedrine Hydrochloride Oral Solution
Acetaminophen, Chlorpheniramine Maleate, and Dextromethorphan Hydrobromide Tablets
Chlorpheniramine Maleate and Pseudoephedrine Hydrochloride Extended-Release Capsules
Penicillin G Procaine, Dihydrostreptomycin Sulfate, Chlorpheniramine Maleate, and Dexamethasone Injectable Suspension

Biochem/physiol Actions

H₁ Histamine receptor antagonist.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

related product

Referencia del producto

Descripción

Precios

signalword

Warning

hcodes

H302

pcodes

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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P0850000

Pheniramine maleate

Y0000436

Chlorphenamine impurity A

USP

1003009

Acetaminophen

USP

1301007

Guaifenesin

Y0001170

Ascorbic acid impurity D

Y0001024

Ascorbic acid impurity C

USP

1021204

4-Aminophenol

USP

1495005

Papain

Dorsal hippocampal microinjection of chlorpheniramine reverses the anxiolytic-like effects of l-histidine and impairs emotional memory in mice.

L Canto-de-Souza et al.

Neuroscience letters, 587, 11-16 (2014-12-20)

Several findings have pointed to the role of histaminergic neurotransmission in the modulation of anxiety-like behaviors and emotional memory. The elevated plus-maze (EPM) test has been widely used to investigate the process of anxiety and also has been used to

Characterization of the commercially-available fluorescent chloroquine-BODIPY conjugate, LynxTag-CQGREEN, as a marker for chloroquine resistance and uptake in a 96-well plate assay.

Cheryl C Y Loh et al.

PloS one, 9(10), e110800-e110800 (2014-10-25)

Chloroquine was a cheap, extremely effective drug against Plasmodium falciparum until resistance arose. One approach to reversing resistance is the inhibition of chloroquine efflux from its site of action, the parasite digestive vacuole. Chloroquine accumulation studies have traditionally relied on

Evaluation of Chlorpheniramine Maleate microparticles in orally disintegrating film and orally disintegrating tablet for pediatrics.

Hao Lou et al.

Drug development and industrial pharmacy, 40(7), 910-918 (2013-04-30)

To mask the bitterness of Chlorpheniramine Maleate via encapsulating drug into Eudragit EPO microparticles, and then incorporate these microparticles into orally disintegrating films (ODF) and orally disintegrating tablets (ODT) for pediatric uses. Spray drying of water-in-oil emulsion was utilized to

Differential thermodynamic driving force of first- and second-generation antihistamines to determine their binding affinity for human H1 receptors.

Shigeru Hishinuma et al.

Biochemical pharmacology, 91(2), 231-241 (2014-07-30)

Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and second-generation antihistamines for human

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