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Merck
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Key Documents

SRP6330

Sigma-Aldrich

CD46 human

recombinant, expressed in E. coli, ≥85% (SDS-PAGE)

Sinónimos:

AHUS2, MCP, MIC10, Membrane cofactor protein isoform 14, TLX, TRA2.10

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

assay

≥85% (SDS-PAGE)

form

liquid

mol wt

33.8 kDa (302 aa, 35-313 aa + His tag)

packaging

pkg of 100 μg

concentration

1 mg/mL

impurities

<1 EU/μg endotoxin (LAL test)

UniProt accession no.

P15529

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... CD46(4179)

General description

Membrane cofactor protein isoform 14, also known as CD46, is a type I membrane protein that has cofactor activity for inactivation of complement components C3b and C4b by serum factor I. This function resides in the complement control protein repeats (CCPs), with CCP1-4 essential for regulation. CD46 is widely distributed on thymocytes, T cells, B cells, monocytes, granulocytes, NK cells, platelets, endothelial cells, epithelial cells, fibroblasts, placenta and sperm, but not on erythrocyte. Recombinant human CD46 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Physical form

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl and 20% glycerol.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Weixin Xiong et al.
Thrombosis and haemostasis, 117(2), 401-414 (2016-11-11)
We showed previously that reduced level of vasostatin-2 (VS-2) correlates to the presence and severity of coronary artery disease. In this study, we aimed to figure out the role of chromogranin A (CGA) derived VS-2 in the development of atherosclerosis
Maximilian Richter et al.
Molecular therapy. Methods & clinical development, 5, 16013-16013 (2016-04-14)
Rituximab is a mouse/human chimeric monoclonal antibody targeted toward CD20. It is efficient as first-line therapy of CD20-positive B-cell malignancies. However, a large fraction of treated patients relapse with rituximab-resistant disease. So far, only modest progress has been made in
Jian Du et al.
Veterinary microbiology, 195, 87-95 (2016-10-25)
The outbreak of Chinese Giant Salamander (Andrias davidianus, CGS) Iridovirus (CGSIV) caused massive death of CGSs. However, some CGSs with low level of CGSIV usually could survive. In our study, major capsid protein (MCP) DNA replicates of CGSIV in shedding
Shao-Yeh Lu et al.
Applied and environmental microbiology, 85(11) (2019-03-25)
Microcin PDI (MccPDI), a class IIa microcin that is produced by Escherichia coli strains 25 and 284, is known to inhibit foodborne pathogenic enterohemorrhagic E. coli serotypes O157:H7 and O26. Here we demonstrate that MccPDI can inhibit Shigella strains and
Sinan Wang et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 27(5), 1305-1315 (2020-12-10)
We recently identified CD46 as a novel therapeutic target in prostate cancer. In this study, we developed a CD46-targeted PET radiopharmaceutical, [89Zr]DFO-YS5, and evaluated its performance for immunoPET imaging in murine prostate cancer models. [89Zr]DFO-YS5 was prepared and its in
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