SML1812

IMR-1

≥98% (HPLC)

• Sinónimos: 2-[2-Methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid ethyl ester, Inhibitor of Mastermind Recruitment-1
• Fórmula empírica (notación de Hill): C₁₅H₁₅NO₅S₂
• Número de CAS: 310456-65-6
• Peso molecular: 353.41
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826080
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(OCC)COC1=CC=C(C=C2SC(NC2=O)=S)C=C1OC
• InChI: 1S/C15H15NO5S2/c1-3-20-13(17)8-21-10-5-4-9(6-11(10)19-2)7-12-14(18)16-15(22)23-12/h4-7H,3,8H2,1-2H3,(H,16,18,22)
• InChI key: QHPJWPQRZMBKTG-UHFFFAOYSA-N

Descripción

Application

Inhibitor of mastermind recruitment-1 (IMR-1) has been used as an inhibitor of Notch transcription activation complex to downregulate the expression of Notch and downstream protein in pheochromocytoma (PC -12) cells.

Biochem/physiol Actions

IMR-1 is a cell penetrant and potent inhibitor of Notch transcriptional activation complex that disrupted the recruitment of Mastermind-like 1 (Maml1) to the Notch transcriptional activation complex on chromatin. IMR-1 potently inhibits the growth of Notch-dependent cancer cell lines, and inhibits growth of patient-derived tumor xenografts. IMR-1 is hydrolyzed in vivo to acid metabolite IMR-1A.

IMR-1 is a cell penetrant and potent inhibitor of Notch transcriptional activation complex.

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable