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Key Documents

Otros documentos

E8280

Sigma-Aldrich

Exo 1

≥98% (HPLC), solid

Sinónimos:

2-(4-Fluorobenzoylamino)benzoic acid methyl ester, 2-(4-Fluorobenzoylamino)methylbenzoate

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About This Item

Fórmula empírica (notación de Hill):
C15H12NFO3
Número de CAS:
75541-83-2
Peso molecular:
273.26
MDL number:
MFCD00028104
UNSPSC Code:
12352203
PubChem Substance ID:
24724477
NACRES:
NA.77

Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

DMSO: soluble 19 mg/mL

SMILES string

COC(=O)c1ccccc1NC(=O)c2ccc(F)cc2

InChI

1S/C15H12FNO3/c1-20-15(19)12-4-2-3-5-13(12)17-14(18)10-6-8-11(16)9-7-10/h2-9H,1H3,(H,17,18)

InChI key

KIAPWMKFHIKQOZ-UHFFFAOYSA-N

Application

Exo 1 has been used as a component of the BRB80 buffer to study coat protein 1 (COPI)-mediated membrane trafficking. It has also been used as a Golgi inhibitor to study its effects on the long interspersed nuclear element-1 (L1) retrotransposition.

Biochem/physiol Actions

Exo 1 is a cell-permeable methylanthranilate analog that promotes the release of adenosine diphosphate (ADP)-ribosylation factor (ARF) 1 from Golgi membranes. It also inhibits the membrane trafficking between the endoplasmic reticulum (ER) and the Golgi bodies.
Reversible inhibitor of exocytosis; Golgi ARF 1 (ADP-Ribosylation Factor) GTPase activator.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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