X4251

XTT sodium salt

analytical standard, ≥90%

• Sinónimos: 2,3-Bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide inner salt
• Fórmula empírica (notación de Hill): C₂₂H₁₆N₇NaO₁₃S₂
• Número de CAS: 111072-31-2
• Peso molecular: 673.52
• MDL number: MFCD00083517
• UNSPSC Code: 41116107
• PubChem Substance ID: 329830806
• NACRES: NA.24

Propiedades

• grade: analytical standard
• Quality Level: 100
• assay: ≥90%
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): forensics and toxicology; pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: [Na+].COc1cc(c(cc1-n2nc(n[n+]2-c3cc(c(cc3OC)[N+]([O-])=O)S([O-])(=O)=O)C(=O)Nc4ccccc4)S([O-])(=O)=O)[N+]([O-])=O
• InChI: 1S/C22H17N7O13S2.Na/c1-41-17-8-15(28(31)32)19(43(35,36)37)10-13(17)26-24-21(22(30)23-12-6-4-3-5-7-12)25-27(26)14-11-20(44(38,39)40)16(29(33)34)9-18(14)42-2;/h3-11H,1-2H3,(H2-,23,30,35,36,37,38,39,40);/q;+1/p-1
• InChI key: JACYMBNQPPWQML-UHFFFAOYSA-M

Descripción

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Useful in AIDS and cancer testing.

XTT has been used in conjunction with phenazine methosulfate (PMS) to screen human cancer cell lines. The tetrazolium dye has also been used to study fungal cell damage, in testing antimicrobial susceptibility of staphylococci, and in Candida biofilm research. Limitations to the XTT assay have been reported.

Principle

In living cells, XTT is metabolically reduced to produce a colorimetric, water-soluble formazan product.

Información de seguridad

• pictograms: GHS02
• signalword: Danger
• hcodes: H242
• pcodes: P210 - P234 - P235 - P240 - P370 + P378 - P403
• Hazard Classifications: Self-react. C
• supp_hazards: EUH044
• Storage Class: 4.1A - Other explosive hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)