SCC224

YUMM 1.1 Mouse Melanoma Cell Line

• Sinónimos: Yale University Mouse Melanoma 1.3 cell line, Yale University Mouse Melanoma cell line
• UNSPSC Code: 41106514

Propiedades

• biological source: mouse
• Quality Level: 100
• packaging: vial of ≥1X10⁶ vial
• manufacturer/tradename: Millipore
• technique(s): cell culture | mammalian: suitable
• shipped in: liquid nitrogen
• storage temp.: −196°C

Descripción

General description

YUMM1.1 cells are syngeneic with the immunocompetent C57BL/6 mouse background and retain genetic markers of the Braf/Pten mouse models, characterized by activation of Braf and inactivation of Pten and Cdkn2a.

Application

• Each vial contains >1X10⁶ viable cells.
• YUMM1.1 cells are tested negative for infectious diseases by a Mouse Essential CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are verified to be of mouse origin and negative for inter-species contamination from rat, chinese hamster, Golden Syrian hamster, human and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
• Cells are negative for mycoplasma contamination.

Features and Benefits

The YUMM cell lines recapitulate genetic drivers found in many human melanomas. YUMM1.1 is driven by Braf activation, Pten/Cdkn2a inactivation, and is highly tumorigenic in vivo.

Target description

The promise of immune-based therapies in cancer and recent progress in successful application of these approaches has confirmed the utility of immunocompetent models for evaluation of the immune system response to cancer cells. Genetically engineered mou

Storage and Stability

YUMM1.1 cells should be stored in liquid nitrogen until use. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Other Notes

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact l

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.