MAB4356

Anti-DPPA-2 Antibody, clone 6C1.2

clone 6C1.2, from mouse

• Sinónimos: Pluripotent embryonic stem cell-related gene 1 protein, developmental pluripotency associated 2
• UNSPSC Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• biological source: mouse
• Quality Level: 100
• antibody form: purified antibody
• antibody product type: primary antibodies
• clone: 6C1.2, monoclonal
• species reactivity: mouse
• technique(s): western blot: suitable
• input: sample type: mouse embryonic stem cell(s)
• isotype: IgG2aκ
• UniProt accession no.: Q7Z7J5; Q9CWH0
• shipped in: wet ice
• target post-translational modification: unmodified
• Gene Information: mouse ... Dppa2(73703)

Descripción

General description

DPPA-2 (developmental pluripotency associated-2) is a novel Oct-4-related protein that is localized to the nucleus of mouse fetal germ cells. DPPA-2 has binding sites for both POU and Sox-2 protein domains and is expressed primarily in the developing germ line following gastrulation. These associations suggest that this protein participates in a very strong supportive role in maintaining cell pluripotentiality. In addition to its role as a pluripotency marker, more recent research using cancer cells suggests that DPPA-2 may also act as an embryo-cancer antigen—pointing to the presence of abnormal cell growth and the formation of cancerous cells.

Specificity

Reactivity with other species has not been tested.

This monoclonal antibody recognizes the mouse DPPA-2 protein.

Immunogen

Full length recombinant mouse DPPA-2 protein.

Application

Research Category
Stem Cell Research

Research Sub Category
Pluripotent & Early Differentiation

This Anti-DPPA-2 Antibody, clone 6C1.2 is validated for use in WB for the detection of DPPA-2.

Quality

(Based upon representative data from a previous lot).
Western Blotting: Recommended working concentration is 2 µg/mL.

Target description

~34 kDa

Physical form

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2a_κ in buffer containing 0.1 M Tris-Glycine (pH 7.4) and
150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable