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Merck
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Key Documents

05-643

Sigma-Aldrich

Anti-phospho-GSK3β (Ser9) Antibody, clone 2D3

clone 2D3, Upstate®, from mouse

Sinónimos:

Anti-7330414F15Rik, Anti-8430431H08Rik, Anti-C86142, Anti-GSK-3, Anti-GSK-3beta, Anti-GSK3

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2D3, monoclonal

species reactivity

human, mouse, rat

manufacturer/tradename

Upstate®

technique(s)

electrophoretic mobility shift assay: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NM_002093

UniProt accession no.

P49841

shipped in

wet ice

target post-translational modification

phosphorylation (pSer9)

Gene Information

human ... GSK3B(2932)

Specificity

GSK3beta

Immunogen

peptide corresponding to amino acids 6-12 (RTT[pS]AE) of human GSK3beta

Application

Anti-phospho-GSK3β (Ser9) Antibody, clone 2D3 is an antibody against phospho-GSK3β (Ser9) for use in EMSA & WB.
Research Category
Signaling
Research Sub Category
PI3K, Akt, & mTOR Signaling

Quality

routinely evaluated by immunoblot on L6 cells stimulated with IGF-1

Target description

46kDa (GSK3β) and 51kDa (GSK3α)

Linkage

Replaces: 04-1075

Physical form

100µg of thiophilic and size exclusion chromatography purified mouse IgG1κ in 100µL of antibody storage buffer (PBS with PEG, Sucrose, and 0.09% sodium azide) and 50% glycerol.
Format: Purified
Thiophilic adsorption chromatography

Storage and Stability

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Descripción
Precios

Storage Class

10 - Combustible liquids

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Hui Sheng et al.
International journal of medical sciences, 10(6), 782-789 (2013-05-01)
We previously reported that the constitutional flavonoid glycosides derived from herb Epimedium (EF, composed of seven flavonoid compounds with common nuclear stem) exerted beneficial effects on the bone, including promoting bone formation and inhibiting bone marrow fat deposition. Recent in
Inhibition of cyclin-dependent kinase 5 but not of glycogen synthase kinase 3-? prevents neurite retraction and tau hyperphosphorylation caused by secretable products of human T-cell leukemia virus type I-infected lymphocytes.
Maldonado, H; Ramirez, E; Utreras, E; Pando, ME; Kettlun, AM; Chiong, M; Kulkarni et al.
Journal of Neuroscience Research null
Pei-Wen Cheng et al.
Biomedicines, 9(11) (2021-11-28)
Traumatic brain injury confers a significant and growing public health burden. It is a major environmental risk factor for dementia. Nonetheless, the mechanism by which primary mechanical injury leads to neurodegeneration and an increased risk of dementia-related diseases is unclear.
Yu-Te Lin et al.
Journal of clinical medicine, 7(10) (2018-10-12)
Recent studies have indicated that several anti-hypertensive drugs may delay the development and progression of Alzheimer's disease (AD). However, the relationships among AD, hypertension, and oxidative stress remain to be elucidated. Here, we aimed to determine whether reactive oxygen species
Adam R Cole et al.
Methods in molecular biology (Clifton, N.J.), 468, 45-65 (2008-12-23)
Glycogen synthase kinase (GSK)-3 is a key signalling intermediate in the action ofWnts. This protein kinase is ubiquitously expressed and has high inherent activity but is inhibited by activation of Wnt signalling or activation of growth factor receptor tyrosine kinases
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