ZBTB33
zinc finger and BTB domain containing 33
Sinónimos:
ZNF-kaiso, ZNF348
Especie:
Human ZBTB33 (10009), Mouse Zbtb33 (56805), Rat Zbtb33 (501506), Zebrafish zbtb33 (562507), Horse ZBTB33 (100062002), domestic cat ZBTB33 (101086378), dog ZBTB33 (100685062), chicken ZBTB33 (422367), cow ZBTB33 (784871), sheep ZBTB33 (101112197) ...Más
ID UniProtKB:
ID del gen:
- Human(10009) Summary: This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-alpha2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010]
- Mouse(56805) zinc finger and BTB domain containing 33
- Rat(501506) zinc finger and BTB domain containing 33
- Zebrafish(562507) zinc finger and BTB domain containing 33
- Horse(100062002) zinc finger and BTB domain containing 33
- domestic cat(101086378) zinc finger and BTB domain containing 33
- dog(100685062) zinc finger and BTB domain containing 33
- chicken(422367) zinc finger and BTB domain containing 33
- cow(784871) zinc finger and BTB domain containing 33
- sheep(101112197) zinc finger and BTB domain containing 33
- naked mole-rat(101708806) zinc finger and BTB domain containing 33
- Domestic Rabbit(100348939) zinc finger and BTB domain containing 33
- domestic guinea pig(100713178) zinc finger and BTB domain containing 33
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-Kaiso Antibody, clone 6F, clone 6F, Upstate®, from mouse,
Reactividad de especies
canine, chicken, hamster, human, monkey, mouse, rat
Aplicación
electrophoretic mobility shift assay
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-Kaiso/ZBTB33 Antibody, clone 10O4V2, Rabbit Monoclonal, ,
Reactividad de especies
human, rat
Aplicación
immunofluorescence
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot