TYMS
thymidylate synthetase
Sinónimos:
HST422, TMS, TS
Especie:
Human TYMS (7298), Mouse Tyms (22171), Rat Tyms (29261), domestic guinea pig Tyms (100720541), naked mole-rat Tyms (101721263), cow TYMS (507631), Zebrafish tyms (81540), chicken TYMS (421060), dog TYMS (607417), domestic cat TYMS (101091231)
ID UniProtKB:
ID del gen:
- Human(7298) Summary: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq, Jul 2008]
- Mouse(22171) thymidylate synthase
- Rat(29261) thymidylate synthetase
- domestic guinea pig(100720541) thymidylate synthetase
- naked mole-rat(101721263) thymidylate synthetase
- cow(507631) thymidylate synthetase
- Zebrafish(81540) thymidylate synthase
- chicken(421060) thymidylate synthetase
- dog(607417) thymidylate synthetase
- domestic cat(101091231) thymidylate synthetase
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Antibodies
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Reactividad de especies
Aplicación
Anti-TYMS antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-TYMS Antibody, clone 1E20 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, monkey, porcine, rat
Aplicación
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Small Molecule - Inhibitor
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Especie