SMAD4
SMAD family member 4
Sinónimos:
DPC4, JIP, MADH4, MYHRS
Especie:
Human SMAD4 (4089), Mouse Smad4 (17128), Rat Smad4 (50554), Zebrafish smad4 (30640), Horse SMAD4 (100033846), domestic cat SMAD4 (101093650), dog SMAD4 (476196), naked mole-rat Smad4 (101703764), domestic guinea pig Smad4 (100717853), cow SMAD4 (540248) ...Más
ID UniProtKB:
ID del gen:
- Human(4089) Summary: This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Oct 2009]
- Mouse(17128) SMAD family member 4
- Rat(50554) SMAD family member 4
- Zebrafish(30640) MAD homolog 4 (Drosophila)
- Horse(100033846) SMAD family member 4
- domestic cat(101093650) SMAD family member 4
- dog(476196) SMAD family member 4
- naked mole-rat(101703764) SMAD family member 4
- domestic guinea pig(100717853) SMAD family member 4
- cow(540248) SMAD family member 4
- sheep(443171) SMAD family member 4
- Goat(100861019) SMAD family member 4
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Monoclonal Anti-SMAD4 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL9774, purified immunoglobulin, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot
western blot
Anti-Smad4/DPC4 Antibody, from rabbit, purified by affinity chromatography,
Reactividad de especies
chimpanzee, human, mouse, rat
Aplicación
immunocytochemistry
western blot
western blot
[KO Validated]Anti-Smad4 Antibody, clone 1H7D3, Rabbit Monoclonal, ,
Reactividad de especies
human, rat
Aplicación
ChIP
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot