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Merck

SLC12A3

solute carrier family 12 (sodium/chloride transporter), member 3

Sinónimos:
NCC, NCCT, TSC
Especie:
Human SLC12A3 (6559), Mouse Slc12a3 (20497), Rat Slc12a3 (54300), domestic guinea pig Slc12a3 (100726300), naked mole-rat Slc12a3 (101704301), cow SLC12A3 (404171), sheep SLC12A3 (101120940), Zebrafish slc12a3 (565439), Horse SLC12A3 (100051953), domestic cat SLC12A3 (101082284) ...Más
ID UniProtKB:
P55017, A8MSJ2, C9JNN9
ID del gen:
  • Human(6559) Summary: This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(20497) solute carrier family 12, member 3
  • Rat(54300) solute carrier family 12 (sodium/chloride transporter), member 3
  • domestic guinea pig(100726300) solute carrier family 12 (sodium/chloride transporters), member 3
  • naked mole-rat(101704301) solute carrier family 12 (sodium/chloride transporters), member 3
  • cow(404171) solute carrier family 12 (sodium/chloride transporters), member 3
  • sheep(101120940) solute carrier family 12 (sodium/chloride transporters), member 3
  • Zebrafish(565439) solute carrier family 12 (sodium/chloride transporters), member 3
  • Horse(100051953) solute carrier family 12 (sodium/chloride transporters), member 3
  • domestic cat(101082284) solute carrier family 12 (sodium/chloride transporters), member 3
  • dog(478118) solute carrier family 12 (sodium/chloride transporters), member 3
  • chicken(415692) solute carrier family 12 (sodium/chloride transporters), member 3

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
AB3553
Anticuerpo anti-cotransportador NaCl sensible a la tiacida, Chemicon®, from rabbit,
Reactividad de especies
human, mouse, rabbit, rat
Aplicación
immunohistochemistry
western blot
ZRB1821
Anti-SLC12A3 Antibody, clone 3I12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, mouse
Aplicación
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
PHR1032
Hydrochlorothiazide, Pharmaceutical Secondary Standard; Certified Reference Material,
Especie
human
1314009
Hydrochlorothiazide, United States Pharmacopeia (USP) Reference Standard,
Especie
human
1681000
Trichlormethiazide, United States Pharmacopeia (USP) Reference Standard,
Especie
human
PHR1179
Chlorothiazide, Pharmaceutical Secondary Standard; Certified Reference Material,
Especie
human
Y0002129
Chlortalidone for system suitability,, European Pharmacopoeia (EP) Reference Standard,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
EHU009551
MISSION® esiRNA, targeting human SLC12A3,
Especie
human