PSMD12
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
Sinónimos:
Rpn5, p55
Especie:
Human PSMD12 (5718), Mouse Psmd12 (66997), Rat Psmd12 (287772), Zebrafish psmd12 (321898), chicken PSMD12 (417425), dog PSMD12 (480465), domestic cat PSMD12 (101100851), domestic guinea pig Psmd12 (100719676), naked mole-rat Psmd12 (101714054), Domestic Rabbit PSMD12 (100338269) ...Más
ID UniProtKB:
ID del gen:
- Human(5718) Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. [provided by RefSeq, Jul 2008]
- Mouse(66997) proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
- Rat(287772) proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
- Zebrafish(321898) proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
- chicken(417425) proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
- dog(480465) proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
- domestic cat(101100851) proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
- domestic guinea pig(100719676) proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
- naked mole-rat(101714054) proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
- Domestic Rabbit(100338269) proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
- cow(538204) proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
- sheep(101107714) proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
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