PSEN1
presenilin 1
Sinónimos:
AD3, FAD, PS-1, PS1, S182
Especie:
Human PSEN1 (5663), Mouse Psen1 (19164), Rat Psen1 (29192), cow PSEN1 (282705), sheep PSEN1 (101102488), naked mole-rat Psen1 (101716186), Domestic Rabbit PSEN1 (100008886), domestic guinea pig Psen1 (100728153), Zebrafish psen1 (30221), domestic cat PSEN1 (101087239) ...Más
ID UniProtKB:
ID del gen:
- Human(5663) Summary: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
- Mouse(19164) presenilin 1
- Rat(29192) presenilin 1
- cow(282705) presenilin 1
- sheep(101102488) presenilin 1
- naked mole-rat(101716186) presenilin 1
- Domestic Rabbit(100008886) presenilin 1
- domestic guinea pig(100728153) presenilin 1
- Zebrafish(30221) presenilin 1
- domestic cat(101087239) presenilin 1
- dog(403408) presenilin 1
- chicken(373977) presenilin 1
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-Presenilin-1 Antibody, NT, clone hPS1-NT, culture supernatant, clone hPS1-NT, Chemicon®,
Reactividad de especies
human
Aplicación
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-Presenilin-1 Antibody, clone PS1-loop ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, mouse
Aplicación
ELISA
affinity binding assay
immunocytochemistry
western blot
affinity binding assay
immunocytochemistry
western blot
Anticuerpo anti-presenilina-1, bucle, a.a. 275-367, CT, serum, Chemicon®,
Reactividad de especies
hamster, human, monkey, mouse
Aplicación
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Presenilin 1 Antibody, Chemicon®, from chicken,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
western blot
western blot
Anti-Presenilin 1 Antibody, clone 3W4V8, Rabbit Monoclonal, ,
Reactividad de especies
human, rat
Aplicación
western blot