PKN1
protein kinase N1
Sinónimos:
DBK, PAK-1, PAK1, PKN, PKN-ALPHA, PRK1, PRKCL1
Especie:
Human PKN1 (5585), Mouse Pkn1 (320795), Rat Pkn1 (29355), Zebrafish pkn1 (322655), dog PKN1 (484903), domestic cat PKN1 (101097547), cow PKN1 (509080), sheep PKN1 (101118101), naked mole-rat Pkn1 (101712866), domestic guinea pig Pkn1 (100713234)
ID UniProtKB:
ID del gen:
- Human(5585) Summary: The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
- Mouse(320795) protein kinase N1
- Rat(29355) protein kinase N1
- Zebrafish(322655) protein kinase N1
- dog(484903) protein kinase N1
- domestic cat(101097547) protein kinase N1
- cow(509080) protein kinase N1
- sheep(101118101) protein kinase N1
- naked mole-rat(101712866) protein kinase N1
- domestic guinea pig(100713234) protein kinase N1
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