PITX2
paired-like homeodomain 2
Sinónimos:
ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, Otlx2, PTX2, RGS, RIEG, RIEG1, RS
Especie:
Human PITX2 (5308), Mouse Pitx2 (18741), Rat Pitx2 (54284), cow PITX2 (506721), sheep PITX2 (101116988), naked mole-rat Pitx2 (101722303), domestic guinea pig Pitx2 (100715589), Zebrafish pitx2 (30164), Horse PITX2 (100146441), domestic cat PITX2 (101081219) ...Más
ID UniProtKB:
ID del gen:
- Human(5308) Summary: This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
- Mouse(18741) paired-like homeodomain transcription factor 2
- Rat(54284) paired-like homeodomain 2
- cow(506721) paired-like homeodomain 2
- sheep(101116988) paired-like homeodomain 2
- naked mole-rat(101722303) paired-like homeodomain 2
- domestic guinea pig(100715589) paired-like homeodomain 2
- Zebrafish(30164) paired-like homeodomain transcription factor 2
- Horse(100146441) paired-like homeodomain 2
- domestic cat(101081219) paired-like homeodomain 2
- chicken(395862) paired-like homeodomain 2
- dog(487902) paired-like homeodomain 2
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