ORC2
origin recognition complex, subunit 2
Sinónimos:
ORC2L
Especie:
Human ORC2 (4999), Mouse Orc2 (18393), Rat Orc2 (301430), fruit fly Orc2 (41703), domestic cat ORC2 (101085739), cow ORC2 (511281), Horse ORC2 (100067880), dog ORC2 (478868), chicken ORC2 (424077), Thale Cress ORC2 (818332) ...Más
ID UniProtKB:
ID del gen:
- Human(4999) Summary: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3, -4, and -5. It also interacts with CDC45 and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication. Alternatively spliced transcript variants have been found, one of which is a nonsense-mediated mRNA decay candidate. [provided by RefSeq, Oct 2010]
- Mouse(18393) origin recognition complex, subunit 2
- Rat(301430) origin recognition complex, subunit 2
- fruit fly(41703) Origin recognition complex subunit 2
- domestic cat(101085739) origin recognition complex, subunit 2
- cow(511281) origin recognition complex, subunit 2
- Horse(100067880) origin recognition complex, subunit 2
- dog(478868) origin recognition complex, subunit 2
- chicken(424077) origin recognition complex, subunit 2
- Thale Cress(818332) origin recognition complex subunit 2
- naked mole-rat(101717321) origin recognition complex, subunit 2
- Domestic Rabbit(100349658) origin recognition complex, subunit 2
- domestic guinea pig(100718829) origin recognition complex, subunit 2
- sheep(101106146) origin recognition complex, subunit 2
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Antibodies
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Reactividad de especies
Aplicación
Anti-ORC2 Antibody, clone 3G6, clone 3G6, Upstate®, from rat,
Reactividad de especies
human
Aplicación
immunoprecipitation (IP)
western blot
western blot
esiRNA
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Especie