NUB1
negative regulator of ubiquitin-like proteins 1
Sinónimos:
BS4, NUB1L, NYREN18
Especie:
Human NUB1 (51667), Mouse Nub1 (53312), Rat Nub1 (296731), Zebrafish nub1 (557021), cow NUB1 (511298), Horse NUB1 (100063567), domestic cat NUB1 (101099625), dog NUB1 (475542), chicken NUB1 (420433), sheep NUB1 (101104058) ...Más
ID UniProtKB:
ID del gen:
- Human(51667) Summary: This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
- Mouse(53312) negative regulator of ubiquitin-like proteins 1
- Rat(296731) negative regulator of ubiquitin-like proteins 1
- Zebrafish(557021) negative regulator of ubiquitin-like proteins 1
- cow(511298) negative regulator of ubiquitin-like proteins 1
- Horse(100063567) negative regulator of ubiquitin-like proteins 1
- domestic cat(101099625) negative regulator of ubiquitin-like proteins 1
- dog(475542) negative regulator of ubiquitin-like proteins 1
- chicken(420433) negative regulator of ubiquitin-like proteins 1
- sheep(101104058) negative regulator of ubiquitin-like proteins 1
- domestic guinea pig(100714758) negative regulator of ubiquitin-like proteins 1
- Domestic Rabbit(100346290) negative regulator of ubiquitin-like proteins 1
- naked mole-rat(101702480) negative regulator of ubiquitin-like proteins 1
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