LIMK2
LIM domain kinase 2
Sinónimos:
Especie:
Human LIMK2 (3985), Mouse Limk2 (16886), Rat Limk2 (29524), Zebrafish limk2 (436924), cow LIMK2 (513539), Horse LIMK2 (100058419), domestic cat LIMK2 (101096766), dog LIMK2 (486363), chicken LIMK2 (396010), sheep LIMK2 (101114815) ...Más
ID UniProtKB:
ID del gen:
- Human(3985) Summary: There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(16886) LIM motif-containing protein kinase 2
- Rat(29524) LIM domain kinase 2
- Zebrafish(436924) LIM domain kinase 2
- cow(513539) LIM domain kinase 2
- Horse(100058419) LIM domain kinase 2
- domestic cat(101096766) LIM domain kinase 2
- dog(486363) LIM domain kinase 2
- chicken(396010) LIM domain kinase 2
- sheep(101114815) LIM domain kinase 2
- domestic guinea pig(100720658) LIM domain kinase 2
- naked mole-rat(101698063) LIM domain kinase 2
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