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Merck

KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Sinónimos:
C-Kit, CD117, PBT, SCFR
Especie:
Human KIT (3815), Mouse Kit (16590), Rat Kit (64030), chicken KIT (378783), domestic cat KIT (493766), cow KIT (280832), Horse KIT (100009704), dog KIT (403811), Goat KIT (100861386), sheep KIT (780504) ...Más
ID UniProtKB:
P10721, B5A956, D5LXN2, D5M931, F5H8F8, Q6IQ28, Q99662, Q9UM99
ID del gen:
  • Human(3815) Summary: This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(16590) kit oncogene
  • Rat(64030) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • chicken(378783) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • domestic cat(493766) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • cow(280832) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • Horse(100009704) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • dog(403811) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • Goat(100861386) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • sheep(780504) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • Domestic Rabbit(100327263) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • domestic guinea pig(100726397) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
  • naked mole-rat(101726400) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Custom & Knockdown Gene Products

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
07-806
Anticuerpo anti-fosfo-c-Kit (Tyr568/Tyr570), Upstate®, from rabbit,
Reactividad de especies
human
Aplicación
western blot
MABF2053
Anti-CD117 (c-Kit) Antibody, clone 2C11, clone 2C11, from mouse,
Reactividad de especies
human, mouse
Aplicación
flow cytometry
western blot
CBL1360
Anti-CD117 Antibody, clone ACK2, clone ACK2, Chemicon®, from rat,
Reactividad de especies
mouse
Aplicación
flow cytometry
immunohistochemistry
immunoprecipitation (IP)
western blot
MABF360
Anti-CD117 (c-kit) Antibody (mouse), APC, clone ACK2, clone ACK2, 0.2 mg/mL, from rat,
Reactividad de especies
mouse
Aplicación
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
MABF511
Anti-CD117 (c-Kit) Antibody (mouse), PE, clone ACK2, clone ACK2, 0.2 mg/mL, from rat,
Reactividad de especies
mouse
Aplicación
flow cytometry
immunocytochemistry
immunohistochemistry

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
CDS022173
Imatinib, ,
Especie
human
PZ0012
Sunitinib malate, ≥98% (HPLC),
Especie
human
CDS023580
Pazopanib, ,
Especie
human
SML2589
Dasatinib, ≥98% (HPLC),
Especie
human
CDS023389
Dasatinib, ,
Especie
human

Proteins

Referencia del producto
Descripción
Especie
14-559-M
c-Kit Protein, active, 10 µg, Active, N-terminal GST tagged, recombinant, human Kit, amino acids 544-end, for use in Kinase Assays.,
Especie
human
14-611-M
c-Kit (D816V) Protein, active, 10 µg, Active, N-terminal GST tagged, recombinant human c-Kit, amino acids 544-end containing the D816V mutation, for use in Kinase Assays.,
Especie
human
14-726-M
c-Kit (D816H) Protein, active, 10 µg, Active, N-terminal GST tagged, recombinant, human c-Kit, amino acids 544-end containing the mutation D816H, for use in Kinase Assays.,
Especie
human
C0499
c-KIT (544-end, V654A), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Especie
human
14-730-M
c-Kit (V560G) Protein, active, 10 µg, Active, N-terminal GST tagged recombinant human c-Kit, amino acids 544 -end, containing the V560G mutation, found in patients with gastrointestinal stromal tumours. For use in Kinase Assays.,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
EMU049661
MISSION® esiRNA, targeting mouse Kit,
Especie
mouse
EHU000841
MISSION® esiRNA, targeting human KIT,
Especie
human