HR
hair growth associated
Sinónimos:
ALUNC, AU, HSA277165, MUHH, MUHH1
Especie:
Human HR (55806), Mouse Hr (15460), Rat Hr (60563), cow HR (785815), dog HR (486130), domestic cat HR (101090097), Horse HR (100053727), domestic guinea pig Hr (100726903), naked mole-rat Hr (101710794), sheep HR (443241)
ID UniProtKB:
ID del gen:
- Human(55806) Summary: This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by multiple regulatory ORFs that exist upstream of the primary ORF. Mutations in one of these upstream ORFs, U2HR, cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
- Mouse(15460) hairless
- Rat(60563) hair growth associated
- cow(785815) hairless homolog (mouse)
- dog(486130) hairless homolog (mouse)
- domestic cat(101090097) hairless homolog (mouse)
- Horse(100053727) hairless homolog (mouse)
- domestic guinea pig(100726903) hair growth associated
- naked mole-rat(101710794) hair growth associated
- sheep(443241) hairless homolog (mouse)
- Domestic Rabbit(100357019) hairless homolog (mouse)
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