COMT
catechol-O-methyltransferase
Sinónimos:
Especie:
Human COMT (1312), Mouse Comt (12846), Rat Comt (24267), fruit fly comt (47091), chicken COMT (416783), domestic cat COMT (101097022), cow COMT (618278), Horse COMT (100146509), dog COMT (445450), naked mole-rat Comt (101717730)
ID UniProtKB:
ID del gen:
- Human(1312) Summary: Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
- Mouse(12846) catechol-O-methyltransferase
- Rat(24267) catechol-O-methyltransferase
- fruit fly(47091) comatose
- chicken(416783) catechol-O-methyltransferase
- domestic cat(101097022) catechol-O-methyltransferase
- cow(618278) catechol-O-methyltransferase
- Horse(100146509) catechol-O-methyltransferase
- dog(445450) catechol-O-methyltransferase
- naked mole-rat(101717730) catechol-O-methyltransferase
- domestic guinea pig(100730509) catechol-O-methyltransferase
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Antibodies
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Descripción
Reactividad de especies
Aplicación
Anti-Catechol O-methyltransferase/COMT Antibody, from rabbit, purified by affinity chromatography,
Reactividad de especies
bovine, horse, human, porcine, rhesus macaque
Aplicación
immunohistochemistry
western blot
western blot
Anti-COMT Antibody, clone 9Y2A3, Rabbit Monoclonal, ,
Reactividad de especies
human, rat
Aplicación
western blot
Small Molecule - Inhibitor
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Especie
esiRNA
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