CASP5
caspase 5, apoptosis-related cysteine peptidase
Sinónimos:
ICE(rel)III, ICEREL-III, ICH-3
Especie:
ID UniProtKB:
ID del gen:
- Human(838) Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010]
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Antibodies
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Anti-Caspase-5 Antibody, from rabbit, purified by affinity chromatography,
Reactividad de especies
human
Aplicación
immunocytochemistry
immunofluorescence
western blot
immunofluorescence
western blot
Proteins
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esiRNA
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