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Merck

BMPR2

bone morphogenetic protein receptor, type II (serine/threonine kinase)

Sinónimos:
BMPR-II, BMPR3, BMR2, BRK-3, PPH1, T-ALK
Especie:
ID UniProtKB:
ID del gen:
  • Human(659) Summary: This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]
  • Mouse(12168) bone morphogenetic protein receptor, type II (serine/threonine kinase)
  • Rat(140590) bone morphogenetic protein receptor, type II (serine/threonine kinase)
  • chicken(374147) bone morphogenetic protein receptor, type II (serine/threonine kinase)
  • dog(478875) bone morphogenetic protein receptor, type II (serine/threonine kinase)
  • cow(407127) bone morphogenetic protein receptor, type II (serine/threonine kinase)
  • domestic cat(101096338) bone morphogenetic protein receptor, type II (serine/threonine kinase)
  • sheep(101103793) bone morphogenetic protein receptor, type II (serine/threonine kinase)
  • sheep(100294556) bone morphogenetic protein receptor, type II (serine/threonine kinase)
  • Domestic Rabbit(100350246) bone morphogenetic protein receptor, type II (serine/threonine kinase)
  • naked mole-rat(101701138) bone morphogenetic protein receptor, type II (serine/threonine kinase)
  • domestic guinea pig(100736232) bone morphogenetic protein receptor, type II (serine/threonine kinase)

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Antibodies

Product Number
Descripción
Reactividad de especies
Aplicación
Anti-BMR2 Antibody, clone 3F6, ascites fluid, clone 3F6, from mouse,
Reactividad de especies
human, monkey, mouse, rat
Aplicación
immunofluorescence
immunohistochemistry

western blot
Anti-BMPR-II Antibody, clone 9F4.1, clone 9F4.1, from mouse,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot

esiRNA

Product Number
Descripción
Especie
MISSION® esiRNA, targeting human BMPR2,
Especie
human
MISSION® esiRNA, targeting mouse Bmpr2,
Especie
mouse