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Merck

APP

amyloid beta (A4) precursor protein

Sinónimos:
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
Especie:
ID UniProtKB:
ID del gen:
  • Human(351) Summary: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(11820) amyloid beta (A4) precursor protein
  • Rat(54226) amyloid beta (A4) precursor protein
  • fruit fly(39399) approximated
  • chicken(374198) amyloid beta (A4) precursor protein
  • domestic cat(101085564) amyloid beta (A4) precursor protein
  • cow(280722) amyloid beta (A4) precursor protein
  • dog(403407) amyloid beta (A4) precursor protein
  • naked mole-rat(101724743) amyloid beta (A4) precursor protein
  • domestic guinea pig(100715302) amyloid beta (A4) precursor protein
  • sheep(101111593) amyloid beta (A4) precursor protein

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ELISA

Referencia del producto
Descripción
Especie
ELISA del amiloideβ42 humano de gran sensibilidad, This High Sensitivity Human Amyloid β42 ELISA is used to measure & quantify Amyloid β42 levels in Neuroscience research.,
Especie
human
Human Amyloid β42 Brain ELISA, This Human Amyloid β42 Brain ELISA is used to measure & quantify Amyloid β42 levels in Neuroscience research.,
Especie
human
High Sensitivity Human Amyloid β40 ELISA, This High Sensitivity Human Amyloid β40 ELISA is used to measure & quantify Amyloid β40 levels in Neuroscience research.,
Especie
human

Small Molecule - Antagonist

Referencia del producto
Descripción
Especie
BTA-1, ≥98% (HPLC), solid,
Especie
human
Curcumin, from Curcuma longa (Turmeric), powder,
Especie
human
Curcumin, ≥94% (curcuminoid content), ≥80% (Curcumin),
Especie
human
Flurbiprofen, cyclooxygenase inhibitor,
Especie
human, rat

Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anticuerpo anti-APP A4, aa 66-81 de APP {NT}, clon 22C11, clone 22C11, Chemicon®, from mouse,
Reactividad de especies
canine, fish, human, monkey, mouse, pig, rat
Aplicación
immunofluorescence
immunohistochemistry

western blot
Anticuerpo anti-beta-amiloide 1-42, Chemicon®, from rabbit,
Reactividad de especies
chicken, human, mouse
Aplicación
ELISA
immunohistochemistry

western blot
Anti-Amyloid β Antibody, clone W0-2, clone WO2, from mouse,
Reactividad de especies
human, mouse
Aplicación
ELISA
immunohistochemistry

western blot
Anti-Amyloid Oligomer Antibody, αβ, oligomeric, serum, Chemicon®,
Reactividad de especies
eukaryotes, human, mouse, rat
Aplicación
ELISA
immunofluorescence

immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-APP-C99 Antibody, clone mC99(70–80), ascites fluid, clone mC99(70-80), from mouse,
Reactividad de especies
human, mouse
Aplicación
immunofluorescence
immunohistochemistry

immunoprecipitation (IP)

western blot

Proteins

Referencia del producto
Descripción
Especie
Fragmento 1-42 de la proteína amiloide β, ,
Especie
human
Amyloid β-Protein Fragment 25-35, ≥97% (HPLC),
Especie
human
Amyloid β Protein Fragment 1-40, ≥90% (HPLC), powder,
Especie
human
β Amyloid 1-42, aβ, ultra pure, HFIP, recombinant human, ,
Especie
human
β Amyloid 1-42, aβ, ultra pure, TFA, recombinant human, ,
Especie
human

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting human APP,
Especie
human
MISSION® esiRNA, targeting mouse App,
Especie
mouse