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Merck

ANPEP

alanyl (membrane) aminopeptidase

Sinónimos:
APN, CD13, GP150, LAP1, P150, PEPN
Especie:
ID UniProtKB:
ID del gen:
  • Human(290) Summary: Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq, Jul 2008]
  • Mouse(16790) alanyl (membrane) aminopeptidase
  • Rat(81641) alanyl (membrane) aminopeptidase
  • chicken(395667) alanyl (membrane) aminopeptidase
  • domestic cat(493785) alanyl (membrane) aminopeptidase
  • Horse(100050397) alanyl (membrane) aminopeptidase
  • cow(404191) alanyl (membrane) aminopeptidase
  • dog(403913) alanyl (membrane) aminopeptidase
  • sheep(101104860) alanyl (membrane) aminopeptidase
  • Domestic Rabbit(100009167) alanyl (membrane) aminopeptidase
  • domestic guinea pig(100727522) alanyl (membrane) aminopeptidase
  • naked mole-rat(101706035) alanyl (membrane) aminopeptidase

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
Milli-Mark® Anti-CD13-FITC Antibody, clone WM-47, clone WM-47, Milli-Mark®, from mouse,
Reactividad de especies
human
Aplicación
flow cytometry
Anti-APN/CD13 Antibody, clone 1D20 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human, rat
Aplicación
affinity binding assay
flow cytometry

immunohistochemistry

western blot
Anti-CD13/ANPEP antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
Anti-APN/CD13 Antibody, clone BR2 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human
Aplicación
ELISA
flow cytometry

immunocytochemistry
Anti-CD13 Rabbit Monoclonal Antibody, clone RM403, affinity purified immunoglobulin,
Reactividad de especies
human
Aplicación
immunohistochemistry
western blot

Small Molecule - Inhibitor

Referencia del producto
Descripción
Especie
Actinonin, ,
Especie
human
N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine, 97%,
Especie
human, mouse, rat
Flavone, ≥99.0%,
Especie
human, rat, mouse

esiRNA

Referencia del producto
Descripción
Especie
MISSION® esiRNA, targeting human ANPEP,
Especie
human
MISSION® esiRNA, targeting mouse Anpep,
Especie
mouse