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Merck

AIFM1

apoptosis-inducing factor, mitochondrion-associated, 1

Sinónimos:
AIF, CMTX4, COWCK, COXPD6, PDCD8
Especie:
Human AIFM1 (9131), Mouse Aifm1 (26926), Rat Aifm1 (83533), Zebrafish aifm1 (373125), cow AIFM1 (535714), Horse AIFM1 (100054546), domestic cat AIFM1 (768258), dog AIFM1 (481048), chicken AIFM1 (428688), naked mole-rat Aifm1 (101698690) ...Más
ID UniProtKB:
O95831, A4QPB4, B1ALN1, B2RB08, D3DTE9, Q1L6K4, Q1L6K6, Q2QKE4
ID del gen:
  • Human(9131) Summary: This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, May 2010]
  • Mouse(26926) apoptosis-inducing factor, mitochondrion-associated 1
  • Rat(83533) apoptosis-inducing factor, mitochondrion-associated 1
  • Zebrafish(373125) apoptosis-inducing factor, mitochondrion-associated 1
  • cow(535714) apoptosis-inducing factor, mitochondrion-associated, 1
  • Horse(100054546) apoptosis-inducing factor, mitochondrion-associated, 1
  • domestic cat(768258) apoptosis-inducing factor, mitochondrion-associated, 1
  • dog(481048) apoptosis-inducing factor, mitochondrion-associated, 1
  • chicken(428688) apoptosis-inducing factor, mitochondrion-associated, 1
  • naked mole-rat(101698690) apoptosis-inducing factor, mitochondrion-associated, 1
  • domestic guinea pig(100730787) apoptosis-inducing factor, mitochondrion-associated, 1
  • sheep(101121574) apoptosis-inducing factor, mitochondrion-associated, 1
  • sheep(100188912) apoptosis-inducing factor, mitochondrion-associated, 1
  • Domestic Rabbit(100347778) apoptosis-inducing factor, mitochondrion-associated, 1

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
ZRB1849
Anti-AIF Antibody, clone 1E4 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
bovine, canine, feline, human, monkey, mouse, porcine, rat
Aplicación
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
07-208
Anti-AIF (Apoptosis Inducing Factor) Antibody, Upstate®, from rabbit,
Reactividad de especies
human, mouse, rat
Aplicación
western blot
AB16501
Anti-AIF Antibody, internal domain, Chemicon®, from rabbit,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot
AB16502
Anti-AIF Antibody, NT, Chemicon®, from rabbit,
Reactividad de especies
human
Aplicación
western blot
SAB5701260
Anti-AIF antibody produced in rabbit, ,
Reactividad de especies
human, mouse, rat
Aplicación
immunohistochemistry
western blot

esiRNA

Referencia del producto
Descripción
Especie
EHU079251
MISSION® esiRNA, targeting human AIFM1,
Especie
human
EMU032921
MISSION® esiRNA, targeting mouse Aifm1,
Especie
mouse