ACTN4
actinin, alpha 4
Sinónimos:
ACTININ-4, FSGS, FSGS1
Especie:
Human ACTN4 (81), Mouse Actn4 (60595), Rat Actn4 (63836), Zebrafish actn4 (322221), cow ACTN4 (522269), domestic cat ACTN4 (101093978), dog ACTN4 (484526), chicken ACTN4 (396024), sheep ACTN4 (101111737), domestic guinea pig Actn4 (100733111)
ID UniProtKB:
ID del gen:
- Human(81) Summary: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
- Mouse(60595) actinin alpha 4
- Rat(63836) actinin alpha 4
- Zebrafish(322221) actinin, alpha 4
- cow(522269) actinin, alpha 4
- domestic cat(101093978) actinin, alpha 4
- dog(484526) actinin, alpha 4
- chicken(396024) actinin, alpha 4
- sheep(101111737) actinin, alpha 4
- domestic guinea pig(100733111) actinin, alpha 4
- naked mole-rat(101710271) actinin, alpha 4
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Antibodies
Referencia del producto
Descripción
Reactividad de especies
Aplicación
Anti-α-Actinin 4 Antibody, clone 1D9 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reactividad de especies
human
Aplicación
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-α-Actinin-4 Antibody, clone 5Y3R6, Rabbit Monoclonal, ,
Reactividad de especies
human, rat
Aplicación
immunofluorescence
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-ACTN4 Mouse mAb (4D10), liquid, clone 4D10, Calbiochem®,
Reactividad de especies
human, mouse, rat
Aplicación
Proteins
Referencia del producto
Descripción
Especie
α-Actinin from chicken gizzard, ~80% α-actinin basis (SDS-PAGE), ammonium sulfate suspension,
Especie
mouse, chicken, rat, human