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Merck

ABAT

4-aminobutyrate aminotransferase

Sinónimos:
GABA-AT, GABAT, NPD009
Especie:
Human ABAT (18), Mouse Abat (268860), Rat Abat (81632), Zebrafish abat (378968), cow ABAT (280969), Horse ABAT (100051470), domestic cat ABAT (101089064), dog ABAT (479856), chicken ABAT (416642), naked mole-rat Abat (101712584) ...Más
ID UniProtKB:
P80404, A8K386, Q16260, Q8N5W2, Q96BG2, Q99800
ID del gen:
  • Human(18) Summary: 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(268860) 4-aminobutyrate aminotransferase
  • Rat(81632) 4-aminobutyrate aminotransferase
  • Zebrafish(378968) 4-aminobutyrate aminotransferase
  • cow(280969) 4-aminobutyrate aminotransferase
  • Horse(100051470) 4-aminobutyrate aminotransferase
  • domestic cat(101089064) 4-aminobutyrate aminotransferase
  • dog(479856) 4-aminobutyrate aminotransferase
  • chicken(416642) 4-aminobutyrate aminotransferase
  • naked mole-rat(101712584) 4-aminobutyrate aminotransferase
  • domestic guinea pig(100725419) 4-aminobutyrate aminotransferase
  • Goat(100861058) 4-aminobutyrate aminotransferase
  • sheep(101105462) 4-aminobutyrate aminotransferase

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Antibodies

Referencia del producto
Descripción
Reactividad de especies
Aplicación
SAB5702893
Anti-GABA transaminase (ABAT) Antibody, clone 10V1K9, Rabbit Monoclonal, ,
Reactividad de especies
human, rat
Aplicación
immunohistochemistry
western blot

esiRNA

Referencia del producto
Descripción
Especie
EMU217131
MISSION® esiRNA, targeting mouse Abat,
Especie
mouse
EHU001161
MISSION® esiRNA, targeting human ABAT,
Especie
human
EMU015101
MISSION® esiRNA, targeting mouse Abat,
Especie
mouse