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  • Temporal Characterization of Microglia/Macrophage Phenotypes in a Mouse Model of Neonatal Hypoxic-Ischemic Brain Injury.

Temporal Characterization of Microglia/Macrophage Phenotypes in a Mouse Model of Neonatal Hypoxic-Ischemic Brain Injury.

Frontiers in cellular neuroscience (2016-12-27)
Nina Hellström Erkenstam, Peter L P Smith, Bobbi Fleiss, Syam Nair, Pernilla Svedin, Wei Wang, Martina Boström, Pierre Gressens, Henrik Hagberg, Kelly L Brown, Karin Sävman, Carina Mallard
PMID28018179
ABSTRACT

Immune cells display a high degree of phenotypic plasticity, which may facilitate their participation in both the progression and resolution of injury-induced inflammation. The purpose of this study was to investigate the temporal expression of genes associated with classical and alternative polarization phenotypes described for macrophages and to identify related cell populations in the brain following neonatal hypoxia-ischemia (HI). HI was induced in 9-day old mice and brain tissue was collected up to 7 days post-insult to investigate expression of genes associated with macrophage activation. Using cell-markers, CD86 (classic activation) and CD206 (alternative activation), we assessed temporal changes of CD11b