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  • Matrix metalloproteinase processing of PTHrP yields a selective regulator of osteogenesis, PTHrP

Matrix metalloproteinase processing of PTHrP yields a selective regulator of osteogenesis, PTHrP

Oncogene (2017-04-04)
J S Frieling, G Shay, V Izumi, S T Aherne, R G Saul, M Budzevich, J Koomen, C C Lynch
PMID28368420
ABSTRACT

Parathyroid hormone-related protein (PTHrP) is a critical regulator of bone resorption and augments osteolysis in skeletal malignancies. Here we report that the mature PTHrP