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New sequence variants associated with bone mineral density.

Nature genetics (2008-12-17)
Unnur Styrkarsdottir, Bjarni V Halldorsson, Solveig Gretarsdottir, Daniel F Gudbjartsson, G Bragi Walters, Thorvaldur Ingvarsson, Thorbjorg Jonsdottir, Jona Saemundsdottir, Steinunn Snorradóttir, Jacqueline R Center, Tuan V Nguyen, Peter Alexandersen, Jeffrey R Gulcher, John A Eisman, Claus Christiansen, Gunnar Sigurdsson, Augustine Kong, Unnur Thorsteinsdottir, Kari Stefansson
PMID19079262
ABSTRACT

In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density.