- A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.
A novel straightforward synthesis of 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF.
Organic letters (2014-06-17)
Xiaowen Xu, Min Zhang, Huanfeng Jiang, Jia Zheng, Yiqun Li
PMID24933098
ABSTRACT
A novel straightforward synthesis of both symmetrical and unsymmetrical 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF as a one-carbon synthon has been developed. The presented method allows synthesizing the products that are currently inaccessible or challenging to prepare with the advantages of operational simplicity, broad substrate scope, and no need for prefunctionalized reagents, making it a highly practical approach to access various 2,4-disubstituted-1,3,5-triazines.
MATERIALS
Product Number
Brand
Product Description
Copper, insulated wire, 100m, conductor diameter 0.24mm, insulation thickness 0.25mm, PTFE (polytetrafluoroethylene) insulation
Copper - O.F.H.C., wire reel, 5m, diameter 0.25mm, as drawn, 99.95+%
Copper, tube, 1000mm, outside diameter 12.7mm, inside diameter 10.26mm, wall thickness 1.22mm, as drawn, 99.9%
Copper, rod, 50mm, diameter 12.7mm, as drawn, 99.99+%
Copper, tube, 1000mm, outside diameter 6.0mm, inside diameter 4mm, wall thickness 1.0mm, as drawn, 99.9%
Copper, rod, 50mm, diameter 6.35mm, as drawn, 99.999%
Copper, tube, 500mm, outside diameter 10.4mm, inside diameter 10mm, wall thickness 0.2mm, as drawn, 99.9%
Copper, wire reel, 0.5m, diameter 0.125mm, as drawn, 99.99+%
Copper, wire reel, 500m, diameter 0.25mm, annealed, 99.9%
Copper, wire reel, 2000m, diameter 0.05mm, annealed, 99.9%
Copper, wire reel, 10m, diameter 0.02mm, annealed, 99.99%
Copper, wire reel, 5000m, diameter 0.04mm, annealed, 99.9%
Copper, wire reel, 200m, diameter 0.5mm, annealed, silver plated, 99.9%
Copper, wire reel, 100m, diameter 0.05mm, annealed, 99.9%
Copper, wire reel, 0.2m, diameter 1.0mm, as drawn, 99.99+%
Copper, wire reel, 20m, diameter 0.5mm, annealed, silver plated, 99.9%
Copper, wire reel, 500m, diameter 0.5mm, annealed, 99.9%
Copper - O.F.H.C., foil, 5m coil, thickness 0.1mm, coil width 100mm, hard, 99.95+%
Copper, wire reel, 10m, diameter 0.5mm, annealed, 99.9%
Copper - O.F.H.C., foil, 6mm disks, thickness 0.075mm, half hard, 99.95+%
Copper, wire reel, 500m, diameter 0.5mm, as drawn, 99.98+%
Copper, wire reel, 500m, diameter 0.125mm, annealed, 99.9%
Copper, wire reel, 20m, diameter 0.5mm, as drawn, 99.999%
Copper, wire reel, 5m, diameter 0.5mm, annealed, 99.9%
Copper, wire reel, 2m, diameter 0.75mm, as drawn, 99.98+%
Copper, wire reel, 100m, diameter 0.5mm, as drawn, 99.98+%
Copper - O.F.H.C., foil, 6mm disks, thickness 0.125mm, hard, 99.95+%
Copper, wire reel, 500m, diameter 0.04mm, annealed, 99.9%
Copper, wire reel, 5m, diameter 0.05mm, as drawn, 99.99+%