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  • Engineering dextran-based scaffolds for drug delivery and tissue repair.

Engineering dextran-based scaffolds for drug delivery and tissue repair.

Nanomedicine (London, England) (2012-12-06)
Guoming Sun, Jeremy J Mao
PMID23210716
ABSTRACT

Owing to its chemically reactive hydroxyl groups, dextran can be modified with different functional groups to form spherical, tubular and 3D network structures. The development of novel functional scaffolds for efficient controlled release and tissue regeneration has been a major research interest, and offers promising therapeutics for many diseases. Dextran-based scaffolds are naturally biodegradable and can serve as bioactive carriers for many protein biomolecules. The reconstruction of the in vitro microenvironment with proper signaling cues for large-scale tissue regenerative scaffolds has yet to be fully developed, and remains a significant challenge in regenerative medicine. This paper will describe recent advances in dextran-based polymers and scaffolds for controlled release and tissue engineering. Special attention is given to the development of dextran-based hydrogels that are precisely manipulated with desired structural properties and encapsulated with defined angiogenic growth factors for therapeutic neovascularization, as well as their potential for wound repair.

MATERIALS
Product Number
Brand
Product Description
D1662
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, average mol wt 35,000-45,000
D4876
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, average mol wt 150,000
D5376
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, average mol wt 1,500,000-2,800,000
D9260
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, average mol wt 9,000-11,000
D3759
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, average mol wt 48,000-90,000
00895
Supelco
Dextran, analytical standard, for GPC, 410,000
00269
Supelco
Dextran, analytical standard, for GPC, 5,000
31387
Sigma-Aldrich
Dextran from Leuconostoc spp., Mr 15,000-25,000
00892
Supelco
Dextran, analytical standard, for GPC, 80,000
00268
Supelco
Dextran, analytical standard, for GPC, 1,000
09184
Sigma-Aldrich
Dextran from Leuconostoc spp., Mr ~100,000
31425
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 670,000
31419
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 25,000
31394
Sigma-Aldrich
Dextran, enzymatic synth.
31417
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 5,000
31392
Sigma-Aldrich
Dextran from Leuconostoc spp., Mr 450,000-650,000
31416
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 1,000
31398
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, Mr ~200,000
31420
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 50,000
31430
Supelco
Dextran, analytical standard, for GPC, Set Mp 1,000-400,000
31389
Sigma-Aldrich
Dextran from Leuconostoc spp., Mr ~40,000
00896
Supelco
Dextran, analytical standard, for GPC, 670,000
00891
Supelco
Dextran, analytical standard, for GPC, 50,000
00893
Supelco
Dextran, analytical standard, for GPC, 150,000
31418
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 12,000
31388
Sigma-Aldrich
Dextran from Leuconostoc spp., Mr ~6,000
D4626
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, average mol wt 15,000-30,000
00270
Supelco
Dextran, analytical standard, for GPC, 12,000