Famotidine in the management of schizophrenia.

To evaluate the use and potential benefit of famotidine in the management of schizophrenia. Clinical literature accessed through MEDLINE (February 1998-October 1998). Key search terms included famotidine, schizophrenia, and histamine. Schizophrenia is a complicated disorder associated with high morbidity if left unmanaged. Histamine2 (H2)-antagonists may be an alternative to conventional treatments. An evaluation of studies focusing on famotidine in the management of schizophrenic symptoms was conducted. Famotidine can improve schizophrenic symptoms that were otherwise refractory to typical antipsychotic agents. Further studies should be conducted to determine if other H2-antagonists are also effective.