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SRP5147

Sigma-Aldrich

Troponin1, His tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

DKFZp451O223, SSTNI, TNN1, TNNI1

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About This Item

CAS Number:
391966-14-6
UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in E. coli

Assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

~24 kDa

NCBI accession no.

NM_003281

application(s)

cell analysis

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... TNNI1(7135)

General description

Troponin1 is a member of the tropomyosin family and regulates the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin1 is part of a complex with troponin T and troponin C in which Troponin1 acts as an inhibitory subunit that blocks actin-myosin interactions and thereby mediates striated muscle relaxation. Troponin1 is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The Troponin1 protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.

Physical form

Supplied in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H315,H319,H360D

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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N Tiso et al.
Biochemical and biophysical research communications, 230(2), 347-350 (1997-01-13)
In this paper the chromosomal localization of the human skeletal muscle genes Troponin-I slow-twitch (TNNI1), Troponin-I fast-twitch (TNNI2), and Troponin-C fast (TNNC2) and the refinement of the position for alpha-Tropomyosin (TPM1) and beta-Tropomyosin (TPM2) are reported. By radiation hybrid mapping
Molecular basis of cardiac performance. Plasticity of the myocardium generated through protein isoform switches.
B Nadal-Ginard et al.
The Journal of clinical investigation, 84(6), 1693-1700 (1989-12-01)

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