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05-449

Sigma-Aldrich

Anti-Bin1 Antibody, clone 99D

clone 99D, Upstate®, from mouse

Synonym(s):

Anti-AMPH2, Anti-AMPHL, Anti-CNM2, Anti-SH3P9

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

99D, monoclonal

species reactivity

rat, human, mouse

manufacturer/tradename

Upstate®

technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NM_139343

UniProt accession no.

O00499

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... BIN1(274)
mouse ... Bin1(30948)

Specificity

Bin1

Immunogen

Partial fusion protein corresponding to amino acids 189-398 of human Bin1. Clone 99D

Application

Anti-Bin1 Antibody, clone 99D is an antibody against Bin1 for use in IP, WB, IH.
Research Category
Apoptosis & Cancer
Research Sub Category
BCL2 & Inhibition

Quality

routinely evaluated by immunoblot on RIPA lysate of C2C12 cells.

Target description

56kDa

Linkage

Replaces: MAB4131

Physical form

0.1M Tris-glycine, pH 7.4, containing 0.05% sodium azide
Format: Purified
Protein G Chromatography

Storage and Stability

1 year at -20°C

Other Notes

Due to license agreement restrictions, this product cannot be purchased for resale.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Suppression of MEK/ERK signalling by Myc: role of Bin-1.
Telfer, JF; Urquhart, J; Crouch, DH
Cellular Signalling null
R Wechsler-Reya et al.
Cancer research, 57(15), 3258-3263 (1997-08-01)
BIN1 is a putative tumor suppressor that was identified in a genetic screen for polypeptides that interact with the MYC oncoprotein. Using a set of six monoclonal antibodies, we identified and examined biochemical features and localization of cellular BIN1. Epitope
Tiago Mendes et al.
Current protocols in cell biology, 86(1), e100-e100 (2019-12-27)
The proximity ligation assay (PLA) allows the detection and subcellular localization of protein-protein interactions with high specificity. We recently developed a high-content screening model based on primary hippocampal neurons cultured in 384-well plates and screened a library of ∼1100 compounds
R J Wechsler-Reya et al.
Molecular and cellular biology, 18(1), 566-575 (1998-01-07)
Bin1 is a Myc-interacting protein with features of a tumor suppressor. The high level of Bin1 expression in skeletal muscle prompted us to investigate its role in muscle differentiation. Significant levels of Bin1 were observed in undifferentiated C2C12 myoblasts, a
Maxime Sartori et al.
Acta neuropathologica, 138(4), 631-652 (2019-05-09)
The bridging integrator 1 gene (BIN1) is a major genetic risk factor for Alzheimer's disease (AD). In this report, we investigated how BIN1-dependent pathophysiological processes might be associated with Tau. We first generated a cohort of control and transgenic mice
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