ZAK
Synonyms:
AZK, MLK7, MLT, MLTK, MRK, mlklak, pk
Species:
Human ZAK (51776), Mouse Zak (65964), Rat Zak (311743), chicken ZAK (424149), dog ZAK (478802), cow ZAK (519251)
UniProtKB ID:
Gene ID:
- Human(51776) Summary: This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
- Mouse(65964) sterile alpha motif and leucine zipper containing kinase AZK
- Rat(311743) sterile alpha motif and leucine zipper containing kinase AZK
- chicken(424149) sterile alpha motif and leucine zipper containing kinase AZK
- dog(478802) sterile alpha motif and leucine zipper containing kinase AZK
- cow(519251) sterile alpha motif and leucine zipper containing kinase AZK
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