XIAP
X-linked inhibitor of apoptosis
Synonyms:
API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3
Species:
Human XIAP (331), Mouse Xiap (11798), Rat Xiap (63879), Zebrafish xiap (373108), domestic cat XIAP (101090594), Horse XIAP (100060870), dog XIAP (442989), chicken XIAP (395280), domestic guinea pig Xiap (100715778), naked mole-rat Xiap (101715865) ...More
UniProtKB ID:
Gene ID:
- Human(331) Summary: This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
- Mouse(11798) X-linked inhibitor of apoptosis
- Rat(63879) X-linked inhibitor of apoptosis
- Zebrafish(373108) X-linked inhibitor of apoptosis
- domestic cat(101090594) X-linked inhibitor of apoptosis
- Horse(100060870) X-linked inhibitor of apoptosis
- dog(442989) X-linked inhibitor of apoptosis
- chicken(395280) X-linked inhibitor of apoptosis
- domestic guinea pig(100715778) X-linked inhibitor of apoptosis
- naked mole-rat(101715865) X-linked inhibitor of apoptosis
- Domestic Rabbit(100328700) X-linked inhibitor of apoptosis
- cow(281647) X-linked inhibitor of apoptosis
- sheep(101116381) X-linked inhibitor of apoptosis
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Small Molecule - Antagonist
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-XIAP Antibody, clone 3H4 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, monkey, rat
Application
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
[KO Validated]Anti-XIAP Antibody, clone 5S5Q7, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunoprecipitation (IP)
western blot
western blot
Proteins
Product Number
Description
Species
XIAP, GST tagged human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human