TNF
tumor necrosis factor
Synonyms:
DIF, TNF-alpha, TNFA, TNFSF2
Species:
Human TNF (7124), Mouse Tnf (21926), Rat Tnf (24835), cow TNF (280943), sheep TNF (443540), Goat TNF (100861232), Domestic Rabbit TNF (100009088), naked mole-rat Tnf (101718432), domestic guinea pig Tnf (100135630), Horse TNF (100033834) ...More
UniProtKB ID:
Gene ID:
- Human(7124) Summary: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Jul 2008]
- Mouse(21926) tumor necrosis factor
- Rat(24835) tumor necrosis factor
- cow(280943) tumor necrosis factor
- sheep(443540) tumor necrosis factor
- Goat(100861232) tumor necrosis factor alpha
- Domestic Rabbit(100009088) tumor necrosis factor
- naked mole-rat(101718432) tumor necrosis factor
- domestic guinea pig(100135630) tumor necrosis factor
- Horse(100033834) tumor necrosis factor
- domestic cat(493755) tumor necrosis factor
- dog(403922) tumor necrosis factor
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Small Molecule - Antagonist
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Tumor Necrosis Factor-α Antibody, clone 195, clone 195, Chemicon®, from mouse,
Species Reactivity
human
Application
immunocytochemistry
immunohistochemistry
neutralization
western blot
immunohistochemistry
neutralization
western blot
Anti-Tumor Necrosis Factor-α Antibody, clone 2C8, clone 2C8, Chemicon®, from mouse,
Species Reactivity
human
Application
ELISA
immunohistochemistry
neutralization
immunohistochemistry
neutralization
Anti-TNFα Antibody, clone MPG-XT3, clone MPG-XT3, Upstate®, from rat,
Species Reactivity
mouse
Application
neutralization
Anti-TNFα Antibody, clone 3B20 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
ELISA
affinity binding assay
immunocytochemistry
western blot
affinity binding assay
immunocytochemistry
western blot
Anti-Tumor Necrosis Factor-α Antibody, Chemicon®, from rabbit,
Species Reactivity
rat
Application
ELISA
western blot
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Proteins
Product Number
Description
Species
Tumor Necrosis Factor-α Protein, Recombinant human, Tumor Necrosis Factor-alpha (TNF-alpha) is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells & certain other target cells.,
Species
human
Tumor Necrosis Factor-α from rat, TNF-α, recombinant, expressed in E. coli, powder, suitable for cell culture,
Species
rat