STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
Synonyms:
D12S1644, IL-4-STAT, STAT6B, STAT6C
Species:
Human STAT6 (6778), Mouse Stat6 (20852), Rat Stat6 (362896), Zebrafish stat6 (337413), Horse STAT6 (100050053), domestic cat STAT6 (101089873), dog STAT6 (100142679), chicken STAT6 (100859196), cow STAT6 (353105), sheep STAT6 (101102134) ...More
UniProtKB ID:
Gene ID:
- Human(6778) Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
- Mouse(20852) signal transducer and activator of transcription 6
- Rat(362896) signal transducer and activator of transcription 6, interleukin-4 induced
- Zebrafish(337413) signal transducer and activator of transcription 6, interleukin-4 induced
- Horse(100050053) signal transducer and activator of transcription 6, interleukin-4 induced
- domestic cat(101089873) signal transducer and activator of transcription 6, interleukin-4 induced
- dog(100142679) signal transducer and activator of transcription 6, interleukin-4 induced
- chicken(100859196) signal transducer and activator of transcription 6, interleukin-4 induced
- cow(353105) signal transducer and activator of transcription 6, interleukin-4 induced
- sheep(101102134) signal transducer and activator of transcription 6, interleukin-4 induced
- naked mole-rat(101725744) signal transducer and activator of transcription 6, interleukin-4 induced
- Domestic Rabbit(100344264) signal transducer and activator of transcription 6, interleukin-4 induced
- domestic guinea pig(100726686) signal transducer and activator of transcription 6, interleukin-4 induced
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho-STAT6 (Tyr641) Antibody, Upstate®, from rabbit,
Species Reactivity
human, mouse
Application
western blot
Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1, clone 19E2.1, from mouse,
Species Reactivity
human, mouse
Application
flow cytometry
western blot
western blot
Anti-phospho-STAT6 (Tyr641) Antibody, clone 16E12, clone 16E12, Upstate®, from mouse,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-STAT6 Antibody, clone 4G7J8, Rabbit Monoclonal, ,
Species Reactivity
mouse
Application
immunofluorescence
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-STAT6 Antibody, clone 1C13 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, monkey
Application
affinity binding assay
flow cytometry
immunohistochemistry
western blot
flow cytometry
immunohistochemistry
western blot