SART1
squamous cell carcinoma antigen recognized by T cells
Synonyms:
Ara1, HOMS1, SART1259, SNRNP110, Snu66
Species:
Human SART1 (9092), Mouse Sart1 (20227), Rat Sart1 (29678), naked mole-rat Sart1 (101706499), domestic guinea pig Sart1 (100725917), cow SART1 (615704), sheep SART1 (101103685), Zebrafish sart1 (436946), domestic cat SART1 (101080575), dog SART1 (483721)
UniProtKB ID:
Gene ID:
- Human(9092) Summary: This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation; its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway. [provided by RefSeq, Jul 2008]
- Mouse(20227) squamous cell carcinoma antigen recognized by T cells 1
- Rat(29678) squamous cell carcinoma antigen recognized by T cells
- naked mole-rat(101706499) squamous cell carcinoma antigen recognized by T cells
- domestic guinea pig(100725917) squamous cell carcinoma antigen recognized by T cells
- cow(615704) squamous cell carcinoma antigen recognized by T cells
- sheep(101103685) squamous cell carcinoma antigen recognized by T cells
- Zebrafish(436946) squamous cell carcinoma antigen recognised by T cells
- domestic cat(101080575) squamous cell carcinoma antigen recognized by T cells
- dog(483721) squamous cell carcinoma antigen recognized by T cells
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-HAF/SART1 Antibody, serum, from rabbit,
Species Reactivity
human, mouse
Application
ChIP
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot