RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
Synonyms:
RIB1, RNS1
Species:
Human RNASE1 (6035), Mouse Rnase1 (19752), Rat Rnase1 (364304), naked mole-rat Rnase1 (101706346), cow RNASE1 (282340), sheep RNASE1 (101113761), cow RNASE1 (280930), fruit fly Rnase1 (5656971), dog RNASE1 (475395), domestic cat RNASE1 (101082663)
UniProtKB ID:
Gene ID:
- Human(6035) Summary: This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
- Mouse(19752) ribonuclease, RNase A family, 1 (pancreatic)
- Rat(364304) ribonuclease, RNase A family, 1 (pancreatic)
- naked mole-rat(101706346) ribonuclease, RNase A family, 1 (pancreatic)
- cow(282340) ribonuclease, RNase A family, 1 (pancreatic)
- sheep(101113761) ribonuclease, RNase A family, 1 (pancreatic)
- cow(280930) ribonuclease, RNase A family, 1 (pancreatic)
- fruit fly(5656971) Ribonuclease 1
- dog(475395) ribonuclease, RNase A family, 1 (pancreatic)
- domestic cat(101082663) ribonuclease, RNase A family, 1 (pancreatic)
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